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abndogos

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Reply with quote  #46 

What are you using? I was using stuff called OncoSupport but stopped it becasue i was not sure if he was breaking out from allergies to it or infection. By regular vet isnt against trying LInezolid, but she is trying to find out more about using it, since she has never had to before. I dont know if i am going to have to drive down to Texas A&M University to get done what I want or what.  

 

 

Teresa

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Reply with quote  #47 

I'm trying the transfer factor (google it). If that doesn't work, I'm going to try to garlic concentrate that Misty uses. That's the last resort because it stinks! Misty can help you out with the dosing to tell your vet for Linezolid.


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Misty

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Reply with quote  #48 
I think I would be chewing out that vet and then going to the AVMA on his sorry ass.  Sorry I don't put up with vets that aren't willing to work for my dog, that's just unacceptable in my book.  If the vet knows anything about MRSP/MRSI that person would be aware that depending on the bacteria's resistance, you have to go to a last ditch drug, and FYI where does that vet think that drug was experimented on before it became a human drug, what a freaking IDIOT!!!  Sorry but if it were me, I would have torn that vet a knew backside.

Camo was on 900mg x 2 daily and he weighed in around 200lbs before he got sick.  My vet consulted with pharmacologist to get the dosage.  Also we started with a 2 week dosage, and it cleared up pretty quickly.  I think he started to break out again a few weeks later, so we did a 2nd 2 week round, and then he was good.  The pharmacologist had recommended 2 weeks past clinical signs, the problem with that is it means 2 weeks past all bumps being gone.  You've dealt with this, even after everything is cleared up, it takes quite a while for the bumps to completely go away because they are deep tissue pyodermas.

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Misty

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Reply with quote  #49 

The immune buster Teresa's referring to is the Allimed that we discussed earlier. 


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Autumn Oaks To Infinity And Beyond "Buzz"
abndogos

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Reply with quote  #50 

OK so here is an update. Did 2 weeks of linezolid, he ended up having a reaction to it(skin drug eruptions). So to a new derm vet we go, did both bacterial and fungal cultures, swabbing nose, ear, rectum, and those drug eruption lesions...so no staph or MRSI, but we do have klebsiella pneumoniae, pseudomonas aeruginosa,escherichia coli(ya rectum), and proteus mirabilis. She picked marbofloxin to treat since they are all suscepticble to it. UGH.

Teresa

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Reply with quote  #51 
Oh boy, well at least those can be treated by regular antibiotics.

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TerryG

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Reply with quote  #52 
Hello Folks, my name is Terry and I thought I'd chime in on the MRSP issue. I currently have two Great Danes and Daphne has MRSP all over her feet. Thankfully it seems to be stabilized to that area and is being held in check by 700mg of Doxy twice per day. So far she's been on this 8 weeks. I worried how long she can be on it before some type of damage is done.And the sad thing is she has had this for going on 4 years now and just recently I found a vet who did the proper culture and found what it was thankfully. The vet wants to put Daphne on Choramphenicol which I'm not a fan of. Especially after reading the horrible side effects and the fact that she's almost seven. So doing the right thing I sent her the link to read all these post and like abndogos this is what the VET Specialist said:
Hey Terry,

I for some reason cannot open the link.

But, I know of Linezolid. I appreciate that the cost may be more
appealing than the other drugs we discussed, but the use of this drug
in veterinary medicine is extremely controversial. This drug is one of
the few oral drugs that can be used in people with serious, life
threatening, MRSA infections. I have never even felt the need to use
it and I will try to avoid it at ALL costs. There is a lot of
resistant bugs these days because of overused and abused antibiotic
use. I am afraid that use of this drug in veterinary medicine could
make it difficult for us to get some of these big gun antibiotics in
the future....they certainly will pull them from our shelves if people
are suffering because of it. So, I am against using it in Daphne given
that we have other antibiotic choices.

Does that make sense?

Sarah
Sorry for the long post but this is so frustrating. I have been dealing with this for over four years, at least 7 vets, and I would venture to say at least 6 grand in cost. And to finally find a great bunch of people who are putting the word out is beyond measure. Then to get smacked down by a knuckleheaded vet who is scared to use a drug that works.
  And from what I'm guessing, this Chloro seems to have horrible side effects that I just don't think Daphne can handle. So idk at this point. I guess I'll have to find Vet #8 or 9 or whatever.
  I'm gonna put her on the immune booster meds that ya'll were talking about. Are there any other type of immune booster that ya'll can recommend besides the Allium?
abndogos

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Reply with quote  #53 

Hi Terry,

Yea, it is very frustrating to say the least. I had to pull teeth to get one of my vets to write me a script for the linezolid. I have been battling infection after infection for almost a year now. The MSRP seems to be gone, but new infections keep popping up. He had klebsiella pneumoniae, echerichia coli(swabbed his butt so of course),proteus mirabilis, and pseudomonas aeruginosa, so he was put on Zeniquin,which got rid of them, but about put him into kidney failure, and now he has regular staph intermedius back again along with providencia stuartii . They had also put him on doxy, which took all of 2 days to give him pancreatitis, which went right along with the azotemia from the other. I just started Toro on the Transfer Factor to see if I can get him to fight this round on his own. I am scared to death to give him any more antibiotics.  I am using Duoxo Chlorhexadine shampoo and Vetericyn spray. Have you tried soaking his feet daily in a chlorhexadine shampoo?

Teresa

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Reply with quote  #54 

Terry, first thing I would tell you is CHANGE VETS!!! I understand her fear, but used properly the drug can save your dog's life. Maybe some vets feel dogs aren't important enough to go the extra mile for, but I disagree. I'm a pharmacist in the hospital setting and though I understand the vet's fears, I also know that Linezolid is a great choice for MRSP IF it is used properly (given in the right dosage for the length of time needed so resistance isn't formed). The other choice is IV Vancomycin and THAT IS NOT PRACTICAL for a dog (it's tough on the kidneys and blood levels must be done frequently to be sure the levels aren't too high). Chloramphenicol is NASTY!! Besides all the side effects, it can cause the bone marrow to stop forming red blood cells. Doxycycline is a logical choice if it works, but it doesn't sound like it's doing anything more than holding the infection at bay. I truly hope you can find a vet that will give you a prescription for Linezolid. I think Misty posted a link for a pharmacy in Canada that you can get it for a reasonable price. Best wishes for you and Daphne.


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Teresa

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Reply with quote  #55 
HOLY COW MAUREEN! It sounds like you baby has doggie AIDS or something.


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Misty

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Reply with quote  #56 
You need to show you vet the clinical triales on linezold, it was on rats  & DOGS not humans. Also if your vet has problems maybe he needs to talk to a vet thats dealt with this firsthand, Maureen's talked to mine. Let me know, as sDr. Bonstead is a fantastc vet & really goes the extra mile 
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UKC CH, Int. CH, BGCH, Lazy D's Southern Mossy Oak, CD, RN, CGCA, TDI, TT, WDX "Camo"
Magical Autumn Oaks Blazing Mirage of Oasis, CGC "Mia"
Autumn Oaks To Infinity And Beyond "Buzz"
TerryG

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Reply with quote  #57 
I agree Teresa, the vet seems to be dead set on Chloramphenicol. So I sent her all the post from this blog hoping to change her mind. If she doesn't I do know of a couple other regular vets we take our babies to for treatment and I believe they would help me out. This vet is a specialist in allergies and dermatology stuff so I figured she would go the extra mile for Daphne. That's what I get for thinking I guess.
We purchased our Danes from Littlehorsedanes out of Texas and they are beautiful Danes and have a super fine pedigree, great attitude with an average life span of 10 to 13 years. At almost 7 I'm praying this infection doesn't take it's toll on Daphne. She's a big time daddies girl.
Good Idea Misty to have the vet contact your vet. I'm out of Central Tn. Does Dr. Bonstead have a website?
Misty

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Reply with quote  #58 

I agree with Teresa also Chloremphenacol is so hard.  Camo was young when he took the drug, but honestly if I would have had to put him on it for a 3rd round, I'm sure it would have killed him.  I'm just glad we did find the majic bullet to help him.

 

My vet is Dr. Sarah Bonstead at Carter vet hospital. I'm sure she'd be willing to talk to your vet too.  It couldn't hurt!

 

http://www.carterpethospital.vetsuite.com/Templates/spotlight.aspx


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Slave to Mastiffs:
UKC CH, Int. CH, BGCH, Lazy D's Southern Mossy Oak, CD, RN, CGCA, TDI, TT, WDX "Camo"
Magical Autumn Oaks Blazing Mirage of Oasis, CGC "Mia"
Autumn Oaks To Infinity And Beyond "Buzz"
TerryG

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Reply with quote  #59 
Well I tried to explain to her about linzolid and seven cut and paste the good post about the drugs. I might as well have been talking to my dogs rear. As you can see below she is stuck on Chloro so now I have to try and fine another vet in my area which is tough, or go with her which I don't want goat this point. I guess its time to start looking. This is so not fair. I'm gonna send her the knucklehead of the year award.

Getting rid of the bacteria can be tough, but not addressing it is a bad idea. I still vote that we switch antibiotics as the doxycycline is not quite doing enough for her....let me know if you think this is something you can do.

I use chloramphenicol a lot because of MRSP....I've only rarely had to stop it due to the side effects....but, dogs do have side effects, we just find ways to cope with them as the dog is treated.

The one person in the post is pushing linezolid way too hard. It is overkill for most (I would guess on the order of 99.9%) of the MRSP in dogs....again, the potential side effects are not fun....but even in the worst MRSP cases there are often 2-3 drugs left that we can use to treat it....it's just that some labs don't test for them and the side effects can be a little scary.

S
Misty

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Reply with quote  #60 
Hmm, well I didn't think anyone was pushing it so much.  I've had several people contact me about MRSP & Chloremphenacol usage, and I think everyone that I've talked to has had issues with it.  Camo couldn't keep food down, dropping a ton of weight, was so weak he could hardly stand, and couldn't pee because it causes muscle issues.  I'd say those were nasty side effects.

So have you had an extended culture done on your dogs, to see what is affective to use, INCLUDING Linezolid?  Camo's initial culture showed he wasn't resistant to Chloremphenacol, and one other drug that would have to be given via IV and is really hard on the kidneys, and we chose not to go down that road.  It was only after he went down hill so much with the Chloremphenacol we knew that wasn't a route we could take again with him.  However he was 2 years old, not a senior like your dogs.

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Slave to Mastiffs:
UKC CH, Int. CH, BGCH, Lazy D's Southern Mossy Oak, CD, RN, CGCA, TDI, TT, WDX "Camo"
Magical Autumn Oaks Blazing Mirage of Oasis, CGC "Mia"
Autumn Oaks To Infinity And Beyond "Buzz"
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